Abstract Title:

Chronic Administration of Rosa Canina Hydro-alcoholic Extract Attenuates Depressive-like Behavior and Recognition Memory Impairment in Diabetic Mice: A Possible Role of Oxidative Stress.

Abstract Source:

Med Princ Pract. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28226322

Abstract Author(s):

Ramin Farajpour, Saeed Sadigh-Eteghad, Nahid Ahmadian, Mohammad Farzipour, Javad Mahmoudi, Alireza Majdi

Article Affiliation:

Ramin Farajpour


OBJECTIVE: This study was designed to evaluate whether or not chronic Rosa Canina (RC) extract administration could improve recognition memory and depressive-like behaviour in diabetic mice.

MATERIALS AND METHODS: Seventy-five (75) male Albino mice (25-30 g) were randomly divided into five groups (15 in each group). A single intraperitoneal (ip) injection of 200 mg/kg streptozotocin (STZ) was administered to the mice to induce diabetes. The control group received normal saline, and the diabetic groups received normal saline or 50, 250 and 500 mg/kg of RC extract for 28 days. The mice were weighed each week. Recognition memory and depressive-like behaviour were assessed using forced swimming and novel object recognition tests (NOR), respectively. Malondialdehyde (MDA) levels and total antioxidant capacity (TAC) were measured in the mice brain homogenate to evaluate oxidative stress. Statistical analysis was conducted using SPSS v22.

RESULTS: The 250 or 500 mg/kg RC-received groups had significantly lower immobility time (159.4±4.7 and 150.1±3.1 second) compared to the sham control group (192.1±7.8 second) in forced swimming test and higher discrimination index (0.39±0.02 and 0.48±0.03) in NOR task in diabetic animals compared to the sham control group (0.2±0.01). Also, treatment with RC (250 and 500 mg/kg) receivedgroups had significantly higher TAC (0.92±0.04 and 0.96±0.05 mMol/l) and lower MDA (0.76±0.02 and 0.67±0.03 nMol/mg protein) levels in the mice brain in comparison to model group. In the 3d and 4th weeks of study, the RC-treated mice (250 and 500 mg/kg) gained more weight (31.2±0.3 and 32.4±0.3 g as well as 31.3±0.2 and 33.7±0.3 g, respectively) than the diabetic (30±0.2 and 29.6±0.3 g) group.

CONCLUSION: This study showed that RC attenuated impairment of recognition memory and depressive-like behaviour probably through modulation of oxidative stress in STZ model of diabetes in mice brain.


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Sayer Ji
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