Abstract Title:

Protective effect of resveratrol on agonist-dependent regulation of vascular contractility via inhibition of rho-kinase activity.

Abstract Source:

Pharmacology. 2010;86(1):37-43. Epub 2010 Jun 30. PMID: 20588074

Abstract Author(s):

Hyun Dong Je, Myeong Hwan Lee, Ji Hoon Jeong, Sun Young Park, Uy Dong Sohn

Article Affiliation:

Department of Pharmacology, College of Pharmacy, Catholic University of Daegu, Gyeongbuk, Korea.

Abstract:

The present study was undertaken to investigate the influence of resveratrol on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Resveratrol at a low concentration (0.03 mmol/l) relaxed directly and more markedly fluoride-induced vascular contraction than phorbol ester-induced contraction. Furthermore, resveratrol more markedly inhibited fluoride-induced increases in pMYPT1 levels than phorbol ester-induced increases. It also more markedly inhibited fluoride-induced increases in pMYPT1 levels than pERK1/2 levels, suggesting that the mechanism involved the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1. This study provides evidence regarding the mechanism underlying the relaxation effect of resveratrol on agonist-induced vascular contraction regardless of endothelial function.

Study Type : In Vitro Study

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