Abstract Title:

Inhibitory effect of (E)-1,2-di(3,5-dimethoxyphenyl)ethene on 3T3-L1 adiopocyte differentiation.

Abstract Source:

Pharmazie. 2010 Dec;65(12):903-5. PMID: 21284260

Abstract Author(s):

Jin Taek Hwang, Sanghee Kim, Sang Yoon Choi

Article Affiliation:

Korea Food Research Institute, Seongnam, Korea.

Abstract:

Resveratrol (trans-3,5,4'-trihydroxystilbene) is a phytoalexin found in diverse plant species, including grapes and peanuts. The antioxidant, anticancer, and cardioprotective properties of resveratrol have been well-characterized. The anti-obesity effect of resveratrol has also been demonstrated in previous studies. In this study, we evaluated the effects of a resveratrol analogue, (E)-1,2-di(3,5-dimethoxyphenyl)ethene, on adipocyte differentiation using 3T3-L1 cells. According to our results, the tested analogue potently inhibits the differentiation of 3T3-L1 adipocyte to a greater degree than resveratrol. Moreover, (E)-1,2-di(3,5-dimethoxyphenyl)ethene strongly downregulated the expression of fatty acid metabolism-related proteins such as fatty acid synthase and acetyl-CoA carboxylase. These results point to the potential of (E)-1,2-di(3,5-dimethoxyphenyl)ethene as an obesity prevention agent.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.