Abstract Title:

Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle.

Abstract Source:

Molecules. 2010;15(10):7115-24. Epub 2010 Oct 14. PMID: 20948499

Abstract Author(s):

Ching-Yi Yiu, Shih-Ying Chen, Li-Kwan Chang, Ya-Fang Chiu, Tsuey-Pin Lin

Article Affiliation:

Department of Otolaryngology, Chi Mei Medical Center, Liouying, Tainan 717, Taiwan.

Abstract:

Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.

Study Type : In Vitro Study

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