Abstract Title:

Cytotoxicity of ascorbic acid in a human colorectal adenocarcinoma cell line (WiDr): in vitro and in vivo studies.

Abstract Source:

Nutr Cancer. 2012 ;64(7):1049-57. Epub 2012 Sep 13. PMID: 22974001

Abstract Author(s):

Ana Catarina Mamede, Ana Salomé Pires, Ana Margarida Abrantes, Sónia Dorilde Tavares, Ana Cristina Gonçalves, João Eduardo Casalta-Lopes, Ana Bela Sarmento-Ribeiro, Jorge Manuel Maia, Maria Filomena Botelho

Article Affiliation:

Ana Catarina Mamede


Vitamin C, available in its reduced form (ascorbic acid; AA) and in its oxidized form (dehydroascorbic acid; DHA), may act in physiological conditions as an antioxidant or pro-oxidant. The aim of this study is to evaluate the cytotoxic effects of pharmacological doses of AA in a human colorectal adenocarcinoma cell line (WiDr) in vitro, through spectrophotometry, clonogenic assays and flow cytometry, and in vivo with xenotransplanted Balb/c nu/nu mice. The results show that the reduced form of vitamin C induces an anti-proliferative and cytotoxic effect in adenocarcinoma colorectal cells under study. The results obtained in vivo after treatment with AA showed a large reduction in the rate of tumor growth. Such understanding can guide decisions about which colorectal cancer patients might potentially benefit from vitamin C pharmacologic therapy.

Study Type : Animal Study, In Vitro Study

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