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Article Publish Status: FREE
Abstract Title:

Immunomodulatory effects of standardized extract ofval. on cytokines, antibody and delayed-type hypersensitivity response in Wistar rats.

Abstract Source:

Res Pharm Sci. 2021 Feb ;16(1):16-25. Epub 2020 Dec 30. PMID: 33953771

Abstract Author(s):

Yuandani, Sony Eka Nugraha, Lia Laila, Denny Satria

Article Affiliation:

Yuandani

Abstract:

Background and purpose: Recently, we have highlighted the immunomodulatory activity ofVal. on phagocytosis ability. The current study was conducted to determine the immunomodulatory effects of the standardized extract ofrhizomes byandstudies.

Experimental approach: Theextract was standardized according to a guideline for herbal preparation. The extract was investigated for its immunomodulatory effects on gene expression of cytokines, cytokines and antibody production as well as delayed-type hypersensitivity (DTH) response. The gene expression of cytokines on lipopolysaccharide-induced-RAW 264.7 cells was analysed by reverse transcription-polymerase chain reaction (RT-PCR) method. The effect of the extract on DTH response was investigated by the paw edema method, meanwhile the effects of the extract on antibody and cytokine production from normal and cyclophosphamide-inducedinfected rats were determined using an enzyme-linked immunosorbent assay (ELISA).

Findings/Results: The extract ofdemonstrated an inhibitory effect on gene expression of interleukin-1β (IL-1β), tumor necrosis factor-α, and IL-6 as compared to lipopolysaccharide-induced cells. The extract also depicted inhibitory activity on IL-4 production as compared to the negative control. Whereas, the DTH response and production of immunoglobulin G from both groups after treatment withextract were higher than those of negative control (<0.05).

Conclusion and implications: The results indicated that theextract has immunomodulatory effects, emphasizing its potential to be developed as immunotherapeutic agent.

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