Abstract Title:

Effect of Rehmannia glutinosa on immediate type allergic reaction.

Abstract Source:

Int J Immunopharmacol. 1998 Apr-May;20(4-5):231-40. PMID: 9730258

Abstract Author(s):

H Kim, E Lee, S Lee, T Shin, Y Kim, J Kim

Abstract:

We investigated the effect of aqueous extract of Rehmannia glutinosa steamed root (RGAE) on the allergic reactions in vivo and in vitro. RGAE dose-dependently inhibited systemic allergic reaction induced by compound 48/80. When RGAE was pre-treated at the same concentrations with systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. RGAE dose-dependently inhibited skin allergic reaction activated by anti-dinitrophenyl (DNP) IgE. RGAE also dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 or anti-DNP IgE. Moreover, RGAE had significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha production of RPMC. These results indicate that RGAE may be beneficial in the regulation of immediate type allergic reaction.

Study Type : Animal Study
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