Abstract Title:

Reduced cutaneous inflammation associated with antioxidant action after topical application of the aqueous extract of Annona muricata leaves.

Abstract Source:

Inflammopharmacology. 2020 Jul 9. Epub 2020 Jul 9. PMID: 32647944

Abstract Author(s):

Luana M Cercato, Jéssica M D Araújo, Alan S Oliveira, Allan J O Melo, Bruno S Lima, Edmilson W P Dos Santos, Agenor G Dos S Neto, Ricardo L C de Albuquerque-Júnior, Marcelo C Duarte, Adriano A S Araujo, Ana Mara O Silva, Renata Grespan, Cristiane B Correa, Enilton A Camargo

Article Affiliation:

Luana M Cercato


Annona muricata L. is used in folk medicine for treatment of diseases related to inflammatory and oxidative processes. This study investigated the effect of the aqueous extract of A. muricata leaves (AEAM) on TPA-induced ear inflammation and antioxidant capacity, both in vitro and in vivo. The in vitro antioxidant capacity of AEAM was measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing/antioxidant power (FRAP) and lipoperoxidation assays. Cytotoxicity and reactive oxygen species (ROS) release were evaluated in the L929 fibroblasts. Swiss mice were submitted to TPA application and were topically treated with AEAM (0.3, 1 or 3 mg/ear). After 6 h, inflammatory and oxidative parameters were evaluated. Quercetin 3-glucoside, rutin, chlorogenic acid, catechin and gallic acid were identified in AEAM. It also presented antioxidant activity in all in vitro assays used. Incubation with AEAM did not cause cell cytotoxicity butreduced ROS release from fibroblasts. Compared with the control group, treatment with AEAM significantly reduced ear oedema and mieloperoxidase activity in inflamed ears, as well as histological parameters of inflammation. These results were associated with the reduction of total hydroperoxides andmodulation of catalase, but not superoxide dismutase activity. These findings show the anti-inflammatory effect of AEAM is associated with antioxidant capacity.

Study Type : In Vitro Study

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