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Abstract Title:

Recovery of immune activity by administration of polysaccharides ofand its characterization of major component.

Abstract Source:

Nat Prod Res. 2020 Jul 13:1-5. Epub 2020 Jul 13. PMID: 32657144

Abstract Author(s):

Rongshen Wang, Min Zuo, Shihong Ding, Bing Liu, Chao Meng, Bo Song, Wanzhong Li

Article Affiliation:

Rongshen Wang

Abstract:

The polysaccharides were acquired from the seeds ofby hot water extraction, ethanol precipitation, decoloration with macroporous 900 resin, and deproteinization with sevag reagent, which possessed significantly immunomodulatory activity on the levels of IgA, IgG, and IgM, the relative indices of thymus and spleen, and the phagocytosis index of mice inseeds polysaccharides (TSP) were separated and purified using DEAE-52 cellulose and Sephacryl S-300 column chromatography to obtain TSP-3a characterized of molecular weight, monosaccharides composition, and other preliminary structural features. TSP-3a (758.6 kDa) mainly contained Man, GalN, GlcA, Rha, Glc, Gal, Ara, and Fuc in a molar ratio of 0.26:0.24:0.19:1.80:0.45:12.56:1.09:0.21. FT-IR analysis suggested TSP-3a was an acid polysaccharide and the presence ofconfiguration within the TSP-3a was discovered. CombiningH NMR,C NMR, and comparison with those reported in the literature, the backbone of TSP-3a might contain→6)--D-Glc-(1→, →3)--D-GlcA-(1→, →6)--D-Gal-(1→,-D-Glc-(1→, and →6)--D-Gal-(1→.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(2249) : AC(733)
Additional Keywords : Polysaccharides : CK(5) : AC(3)

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