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Abstract Title:

Rapid bactericidal effect of cinnamon bark essential oil against Pseudomonas aeruginosa.

Abstract Source:

J Appl Microbiol. 2019 Dec 2. Epub 2019 Dec 2. PMID: 31793161

Abstract Author(s):

E R Elcocks, P T N Spencer-Phillips, E C Adukwu

Article Affiliation:

E R Elcocks

Abstract:

AIMS: This study aimed to identify the most effective antimicrobial agent from a selection of essential oils (EO) and investigate its bactericidal properties against Pseudomonas aeruginosa.

METHODS AND RESULTS: The disc diffusion assay and minimal inhibitory/bactericidal concentration tests were used to identify antimicrobial potential. Several oils exhibited antimicrobial effects at concentrations as low as 0·03% (v/v). Significantly, cinnamon (Cinnamomum zeylanicum) bark EO exhibited a broad-spectrum activity against Gram-negative and Gram-positive bacteria and showed bacteriostatic and bactericidal effects against P. aeruginosa PAO1 at 0·125% (v/v) and all other tested organisms, including known multidrug resistant species. Time-kill assays and metabolic activity tests showed cinnamon oil to exhibit rapid killing, with bactericidal activity observed in ≤6 min at ≥0·5% (v/v). Furthermore, scanning electron microscopy and a membrane permeability assay indicated damage to membrane integrity, loss of turgor and cell collapse.

CONCLUSION: Cinnamon bark EO is a broad-spectrum antimicrobial agent capable of rapid killing at low concentrations.

SIGNIFICANCE AND IMPACT OF THE STUDY: This study provides a sound basis for further investigation of the potential of cinnamon bark EO as an alternative to conventional antimicrobial products due to its fast-acting bactericidal properties at low concentrations.

Study Type : In Vitro Study

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Sayer Ji
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