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Abstract Title:

Chemical Characterization of Bioactive Components ofExtract and Its Protective Effect on Dextran Sulfate Sodium-Induced Intestinal Bowel Disease in a Mouse Model.

Abstract Source:

J Med Food. 2020 May 5. Epub 2020 May 5. PMID: 32379993

Abstract Author(s):

Dalanda Wanes, Mohamed-Amine Jabri, Haifa Tounsi, Kais Rtibi, Nacim Zouari, Najla Hajji, Mourad Jridi, Afifa Abdellaoui, Hichem Sebai

Article Affiliation:

Dalanda Wanes

Abstract:

is a well-known medicinal plant used in folk remedy that alleviates various disorders, including inflammation, gastritis, and diarrhea. The objective of this investigation was to identify and quantify the phenolic components ofmethanolic extract (RCME) and to determine its protective action with dextran sulfate sodium (DSS)-generated mice colitis model. RCME chemical analysis was done using Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry, and experimental animals received RCME at different doses before colitis induction by oral DSS administration during 7 days. Another group received sulfasalazine as a positive control. Colitis damages and RCME benefits were assessed using histopathological and biochemical changes and improvements. Many phenolic compounds have been identified. In addition, the DSS intoxication induced an alteration of colonic epithelium associated with an oxidative stress state. DSS administration led to an increase or decrease of intracellular mediators such as free iron and ionizable calcium. RCME consumption effectively protected against colonic histological/biochemical alterations induced by DSS intoxication providing support for the traditional use of this plant.

Study Type : Animal Study

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