Abstract Title:

Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats.

Abstract Source:

Arch Toxicol. 2011 Feb 1. Epub 2011 Feb 1. PMID: 21286687

Abstract Author(s):

Gustavo Rafael Mazzaron Barcelos, Denise Grotto, Juliana Mara Serpeloni, José Pedro Friedmann Angeli, Bruno Alves Rocha, Vanessa Cristina de Oliveira Souza, Juliana Tanara Vicentini, Tatiana Emanuelli, Jairo Kenupp Bastos, Lusânia Maria Greggi Antunes, Siegfried Knasmüller, Fernando Barbosa

Article Affiliation:

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café, s/no, Ribeirão Preto, São Paulo, CEP 14040-903, Brazil.

Abstract:

Aim of the study was to find out whether consumption of quercetin (QC), an abundant flavonoid in the human diet, protects against DNA damage caused by exposure to organic mercury. Therefore, rats were treated orally with methylmercury (MeHg) and the flavonoid with doses that reflect the human exposure. The animals received MeHg (30 μg/kg/bw/day), QC (0.5-50 mg/kg/bw/day), or combinations of both over 45 days. Subsequently, the glutathione levels (GSH) and the activities of glutathione peroxidase (GPx) and catalase (CAT) were determined, and DNA damage was measured in hepatocytes and peripheral leukocytes in single cell gel electrophoresis assays. MeHg decreased the concentration of GSH and the activity of GPx by 17 and 12%, respectively and caused DNA damage to liver and blood cells, while with QC no such effects were seen. When the flavonoid was given in combination with MeHg, the intermediate and the highest concentrations (5.0 and 50.0 mg/kg/bw/day) were found to cause DNA protection; DNA migration was reduced by 54 and 65% in the hepatocytes and by 27 and 36% in the leukocytes; furthermore, the reduction in GSH and GPx levels caused by MeHg treatment was restored. In summary, our results indicate that consumption of QC-rich foods may protect Hg-exposed humans against the adverse health effects of the metal.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Genoprotective : CK(413) : AC(148)

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Sayer Ji
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