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Abstract Title:

Mango (L.): a magnificent plant with cancer preventive and anticancer therapeutic potential.

Abstract Source:

Crit Rev Food Sci Nutr. 2020 Jun 8:1-27. Epub 2020 Jun 8. PMID: 32506936

Abstract Author(s):

Bilal Mirza, Courtney R Croley, Maha Ahmad, Joshua Pumarol, Niranjan Das, Gautam Sethi, Anupam Bishayee

Article Affiliation:

Bilal Mirza

Abstract:

L. (mango), a long-living evergreen plant belonging to the Anacardiaceae family, has been cultivated for thousands of years in the Indian subcontinent for its excellent fruits which represent a rich source of fiber, vitamin A and C, essential amino acids, and a plethora of phytochemicals.is extensively used in various traditional systems of medicine to prevent and treat several diseases. The health-promoting and disease-preventing effects ofare attributed to a number of bioactive phytochemicals, including polyphenols, terpenoids, carotenoid and phytosterols, found in the leaf, bark, edible flesh, peel, and seed.has been shown to exhibit various biological and pharmacological activities, such as antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, antidiabetic, antiobesity, and anticancer effects. There are a few studies conducted that have indicated the nontoxic nature of mango constituents. However, while there are numerous individual studies investigating anticancer effects of various constituents from the mango tree, an up-to-date, comprehensive and critical review of available research data has not been performed according to our knowledge. The purpose of this review is to present a comprehensive and critical evaluation of cancer preventive and anticancer therapeutic potential ofand its phytochemicals with special focus on the cellular and molecular mechanisms of action. The bioavailability, pharmacokinetics, and safety profile of individual phytocomponents ofas well as current limitations, challenges, and future directions of research have also been discussed.

Study Type : Review
Additional Links
Pharmacological Actions : Chemopreventive : CK(4220) : AC(1326)

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