Abstract Title:

Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging.

Abstract Source:

J Agric Food Chem. 2008 Nov 26;56(22):10544-51. PMID: 18954071

Abstract Author(s):

James A Joseph, Derek R Fisher, Vivian Cheng, Agnes M Rimando, Barbara Shukitt-Hale

Article Affiliation:

US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA. jim.joseph@ars.usda.gov

Abstract:

Research suggests that polyphenolic compounds contained in fruits and vegetables that are rich in color may have potent antioxidant and anti-inflammatory activities. The present studies determined if stilbene (e.g., resveratrol) compounds would be efficacious in reversing the deleterious effects of aging in 19 month old Fischer 344 rats. Experiment I utilized resveratrol and six resveratrol analogues and examined their efficacies in preventing dopamine-induced decrements in calcium clearance following oxotremorine-induced depolarization in COS-7 cells transfected with M1 muscarinic receptors (MAChR) that we have shown previously to be sensitive to oxidative stressors. Experiment II utilized the most efficacious analogue (pterostilbene) from experiment I and fed aged rats a diet with a low (0.004%) or a high (0.016%) concentration of pterostilbene. Results indicated that pterostilbene was effective in reversing cognitive behavioral deficits, as well as dopamine release, and working memory was correlated with pterostilbene levels in the hippocampus.

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