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Abstract Title:

Pterostilbene, a potential MCR-1 inhibitor that enhances the efficacy of polymyxin B.

Abstract Source:

Antimicrob Agents Chemother. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29339386

Abstract Author(s):

Yonglin Zhou, Shui Liu, Tingting Wang, Hui Li, Shusheng Tang, Jianfeng Wang, Yang Wang, Xuming Deng

Article Affiliation:

Yonglin Zhou

Abstract:

We characterized pterostilbene produced a synergistic effect with polymyxin B (FIC index=0.156 or 0.188) against MCR-producing Escherichia coli strains of both human and animal origin. The time-killing assays showed that either pterostilbene or polymyxin B failed to eradicate a mcr-1- and NDM-positive E. coli strain ZJ487, but the combination eliminated by 1-hour post-inoculation. The survival rate of mouse following the intraperitoneal infection significantly promoted from 0% to 60% in the group of combination therapy applied.

Study Type : Review

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