Article Publish Status: FREE
Abstract Title:

Protective effect of soursop (linn.) juice on oxidative stress in heat stressed rabbits.

Abstract Source:

J Anim Sci Technol. 2018 ;60:28. Epub 2018 Nov 16. PMID: 30473869

Abstract Author(s):

Olatunji Abubakar Jimoh, Eyanlola Soladoye Ayedun, Waheed Abimbola Oyelade, Olugbenga David Oloruntola, Olajumoke Temidayo Daramola, Simeon Olugbemiga Ayodele, Idowu Samuel Omoniyi

Article Affiliation:

Olatunji Abubakar Jimoh


Background: Preventing oxidative stress in heat stressed animals may be possible by increasing antioxidant defence via exogenous administration of antioxidant substrate and/or its precursors. The study aimed to investigate the effect of Soursop juice in mitigating oxidative stress induced by heat stress in rabbit.

Methods: Sixty mixed breed rabbit bucks aged 12-18 months old with the average weight of 1826 ± 8.35 g/rabbit, randomly allotted to experimental treatments of four replicates each, in a completely randomized design during high-temperature humidity index in Ado Ekiti, Southwest Nigeria. Soursop juice (SSJ) was administered via oral drenched daily per kg body weight (BW), to designated treatment 1 to 5; 0.55 mlkgBW distilled water (control), 0.55 mlkgBW SSJ, 1.11 mlkgBW SSJ, 1.67 mlkgBW SSJ and 2.22 mlkgBW SSJ, respectively. Fastened blood samples were collected at days 28 and 56, and assay for serum protein, cholesterol, triglycerides, superoxide dismutase, catalase, reduced glutathione and lipid peroxidation using standard procedures.

Result: Result revealed that SSJ demonstrated hypocholesterolemic effect in a dose-dependent manner throughout the study. Effect of chronic administration of SSJ to heat stressed rabbits proved beneficial, as SSJ reduced serum lipid peroxidation and enhanced antioxidant activity over 8 weeks.

Conclusion: Administration of soursop juice to heat-stressed bucks at 2.22 mlkgBW offered optimum antioxidant defense against oxidative stress.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758)

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