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Abstract Title:

Protective Effect of Naringin on DSS-Induced Ulcerative Colitis in Mice.

Abstract Source:

J Agric Food Chem. 2018 Nov 26. Epub 2018 Nov 26. PMID: 30472831

Abstract Author(s):

Hongyang Cao, Jiuxi Liu, Peng Shen, Jiapei Cai, Yuchang Han, Kunpeng Zhu, Yunhe Fu, Naisheng Zhang, Zecai Zhang, Yongguo Cao

Article Affiliation:

Hongyang Cao

Abstract:

Peroxisome proliferator-activated receptorγ (PPARγ) is an important member of the nuclear receptor superfamily. Previous studies have showed the satisfactory anti-inflammatory role of PPARγ in experimental colitis models, mainly through negatively regulating several transcription factors such as nuclear factor-κB (NF-κB). Therefore, regulating PPARγ and PPARγ-related pathways has a great promise for treating ulcerative colitis (UC). In the present study, our objective was to explore the potential effect of naringin on dextran sulfate sodium (DSS)-induced UC in mice and its involved potential mechanism. We found that naringin significantly relieved DSS-induced disease activities index (DAI), colon length shortening and colonic pathological damage. Exploration on the potential mechanisms demonstrated that naringin significantly activated DSS-induced PPARγ and subsequently suppressed NF-κB activation. PPARγ inhibitor GW9662 largely abrogated the roles of naringin in vitro. Moreover, DSS-induced the activation of mitogen-activated protein kinase (MAPK) and (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome was inhibited by naringin. Tight junction (TJ) architecture in naringin groups was also maintained by regulating zonula occludens-1 (ZO-1) expression. These results suggested that naringin may be a potential natural agent for protecting mice from DSS-induced UC.

Study Type : Animal Study

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