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Article Publish Status: FREE
Abstract Title:

Promising effect ofextract on high-fat diet-induced nonalcoholic fatty liver.

Abstract Source:

J Tradit Complement Med. 2017 Oct ;7(4):508-514. Epub 2017 Feb 13. PMID: 29034200

Abstract Author(s):

Ida Davoodi, Roja Rahimi, Mohammad Abdollahi, Fatemeh Farzaei, Mohammad Hosein Farzaei, Zahra Memariani, Fariba Najafi

Article Affiliation:

Ida Davoodi

Abstract:

NAFLD is a chronic liver disease that affects a high proportion of the world's population which causes metabolic and hepatic damages.Mill is traditionally used as a dietary supplement for liver disorders. This study was carried out to determine the beneficial effect of standardized extract ofon animal model of nonalcoholic fatty liver disease (NAFLD). NAFLD was induced by high-fat diet (HFD) in Wistar rats. HFD rats showed an increase ( < 0.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and reduced the high-density lipoprotein (HDL) levels.significantly reduced the elevation of final body weight, liver fat accumulation, TG, TC, LDL-C concentrations and hepatic enzymes ( < 0.05). Histopathological examination of hepatic tissue confirmed the therapeutic effect ofImprovement of total antioxidant power activity, total thiol content, MPO enzyme activity, and also lipid peroxidation were also considered in treated animals ( < 0.05). HPLC analysis showed that phenolic compounds including gallic acid, quercetin and syringic acid are the main bioactive compounds ofhydroalcoholic extract. In conclusion,dietary supplementation has a therapeutic effect in NAFLD. Improvement of oxidative stress associated damage in liver tissue is among the main pharmacological mechanisms involved in therapeutic activity of the plant.

Study Type : Animal Study

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