Abstract Title:

Probiotic multistrain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics: a placebo-controlled pilot study.

Abstract Source:

Inflamm Allergy Drug Targets. 2012 Mar 28. Epub 2012 Mar 28. PMID: 22452604

Abstract Author(s):

Rosa Rosania, Maria Filomena Minenna, Floriana Giorgio, Antonio Facciorusso, Vincenzo De Francesco, Cesare Hassan, Carmine Panella, Enzo Ierardi

Article Affiliation:

Gastroenterology Section, Department of Medical Sciences, University of Foggia, Viale Pinto, 1, 71100 Foggia, Italy. enzo.ierardi@fastwenet.it.


Probiotics survive in gastric environment competing with H. pylori. We studied probiotic"multistrain"administration in dyspeptics with H. pylori (placebo-controlled study). Forty patients with H. pylori (urea breath test - UBT - and IgG) were treated for 10 days with a mixture of 8 species of probiotics. Control group of represented by 40 positive subjects received placebo. A second UBT and H. pylori stool antigen (HpSA) detection were performed after 1 month. Still positive patients who remained infected were treated with triple therapy undergoing another UBT after 30 days. A second line therapy was administered in remaining positive patients. Statistics: Fisher's exact probability and Student's t tests. Thirteen out 40 patients using probiotics became negative, while controls remained positive, irrespectively of independently by the initial UBT delta value. Triple therapy did not show No different difference in the eradication rates between the two groups was found (68%-71%). After second line therapy two patients remained positive. An adequate supplementation with probiotics might eradicate H. pylori.

Study Type : Human Study

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