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Article Publish Status: FREE
Abstract Title:

Myricetin Possesses Anthelmintic Activity and Attenuates Hepatic FibrosisModulating TGFβ1 and Akt Signaling and Shifting Th1/Th2 Balance in-Infected Mice.

Abstract Source:

Front Immunol. 2020 ;11:593. Epub 2020 Apr 16. PMID: 32373112

Abstract Author(s):

Ping Huang, Minyu Zhou, Shaoyun Cheng, Yue Hu, Minzhao Gao, Yubin Ma, Yanin Limpanont, Hongli Zhou, Paron Dekumyoy, Yixin Cheng, Zhiyue Lv

Article Affiliation:

Ping Huang

Abstract:

Schistosomiasis is a zoonotic and debilitating parasitic disease caused by. Praziquantel remains the choice for treating schistosomiasis, but its efficacy could be hampered by emergence of resistance. In this study, using large-scale drug screening, we selected out myricetin, a natural flavonol compound, having a good anti-schistosome effect. We found that myricetin exhibited dose and time-dependent insecticidal effect on, with an LCof 600μM for 24 h, and inhibited female spawning. The drug mainly destroyed the body structure of the worms and induced apoptosis of the worm cells, which in turn led to death. In addition, oral administration of myricetin in mice infected withshowed a deworming effect, as evidenced by a significant reduction in the liver egg load. H&E staining, quantitative RT-PCR, and Western blotting assays showed that myricetin significantly alleviated liver fibrosis in mice infected with. Myricetin also effectively inhibited the expression of TGFβ1, Smad2, phospho-Smad2, Smad3, phospho-Smad3, ERK, phospho-ERK, Akt, and phospho-Akt in the liver of infected mice, suggesting that myricetin attenuated liver fibrosis in micemodulating TGFβ1 and Akt signaling. Flow cytometric analysis of Th subtypes (Th1/Th2/Th17/Treg) in the mouse spleen further revealed that myricetin significantly increased the percentage Th1 cells in infected mice and reduced the proportion of Th2 cells and Th17 cells. Immunology multiplex assay further showed that myricetin attenuated-induced rise in the plasma levels of IL-4, IL-5, IL-10, IL-13, and IL-17A in infected mice while increasing the plasma contents of IFN-γ, IL-12, and IL-7. In conclusion, our study provides the first direct evidence that myricin possesses potent anti-schistosome activitiesand, and offers new insights into the mechanisms of action by myricetin. The present findings suggest that myricetin could be further explored as a therapeutic agent for.

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