Abstract Title:

Possible predictors of cardiorespiratory events after immunization in preterm neonates.

Abstract Source:

Neonatology. 2013 ;104(2):151-5. Epub 2013 Jul 24. PMID: 23887711

Abstract Author(s):

Tiphaine Mialet-Marty, Alain Beuchée, Wissal Ben Jmaa, Nga N'guyen, Xavier Navarro, Fabienne Porée, Anne Monique Nuyt, Patrick Pladys

Article Affiliation:

Tiphaine Mialet-Marty


BACKGROUND: The influence of the first immunization on cardiorespiratory (CR) stability in very preterm infants is still a controversial subject.

OBJECTIVES: To describe the changes induced by immunization on heart and respiratory rate variability (HRV-RRV) and to test a potential association between preimmunization profiles and postimmunization CR events.

METHODS: Continuous 72-hour CR recordings and 2.5-hour polysomnographic recordings were performed on very preterm infants immunized after 7 weeks. The results are expressed as medians (interquartile ranges).

RESULTS: Immunization was performed on 31 very preterm infants [28 weeks' gestation (26.9-29), birth weight: 965 g (795-1,105)], and was associated with an increased incidence (p<0.01) of events lasting more than 10 s: bradycardia<80 bpm [2.2 (1.1-7) vs. 1.8 (1-4)/12 h], desaturation [17.6 (9.4-36.4) vs. 13.9 (7.7-33.8)/12 h] and associated bradycardia-desaturation [IB+D, 4.1 (1.4-7.3) vs. 2.4 (1-4.6)/12 h], with mild changes in HRV and no change in RRV. The changes in IB+D frequency were correlated with preimmunization IB+D frequency (r = 0.44, p<0.05), HRV spectral parameter low frequency/high frequency ratio (LF/HF, r = 0.55, p<0.01) and approximate entropy of HRV (r = -0.39, p<0.05).

CONCLUSION: The increase in CR events after the first immunization in very preterm infants was associated with: (1) sympathetic predominance in heart rate control (high LF/HF ratio), (2) abnormal oversimplification of HRV (low entropy) and (3) persistent respiratory rhythm control immaturity (high IB+D before vaccine).

Study Type : Human Study
Additional Links
Anti Therapeutic Actions : Vaccination: All : CK(6351) : AC(662)

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Sayer Ji
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