Article Publish Status: FREE
Abstract Title:

The positive effect of eugenol on acute pancreatic tissue injury: a rat experimental model.

Abstract Source:

Pan Afr Med J. 2021 ;38:132. Epub 2021 Feb 5. PMID: 33912302

Abstract Author(s):

Alexandra Tsaroucha, Vasileios Kaldis, Michail Vailas, Dimitrios Schizas, Maria Lambropoulou, Apostolos Papalois, Christina Tsigalou, Apostolos Gaitanidis, Michael Pitiakoudis, Constantinos Simopoulos

Article Affiliation:

Alexandra Tsaroucha


Introduction: we present a rat experimental model used to evaluate the possible reduction in the extent of pancreatic tissue injury in acute pancreatitis cases, after administration of eugenol.

Methods: one hundred and twenty Wistar rats were used, which were randomly assigned in 3 groups: sham (n=20), control (n=50) and eugenol (n=50). Acute pancreatitis was induced by biliopancreatic ligation in the control and eugenol groups, but not in the Sham group. In the eugenol group, eugenol was administered per-os. Five histopathological parameters, such as edema, inflammatory infiltration, duct dilatation, hemorrhage and acinar necrosis were evaluated.

Results: at 72 h from acute pancreatitis induction, the total histological score was diminished in the eugenol group (p<0.0005) and duct dilatation and inflammatory infiltration were reduced compared to the control group (p<0.05). In addition, at 72 h, eugenol reduced pancreatic myeloperoxidase activity (p<0.0005).

Conclusion: eugenol, a highly free radical scavenger agent, may have a preventive role in acute pancreatic injury, as it was evident in our rat experimental model.

Study Type : Animal Study

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