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Abstract Title:

Polysaccharide fromTratt Fruit Attenuates Hyperglycemia and Hyperlipidemia and Regulates Colon Microbiota in DiabeticMice.

Abstract Source:

J Agric Food Chem. 2020 Jan 8 ;68(1):147-159. Epub 2019 Dec 26. PMID: 31826616

Abstract Author(s):

Lei Wang, Chao Li, Qiang Huang, Xiong Fu

Article Affiliation:

Lei Wang

Abstract:

This study was aimed at investigating the hypoglycemic and hypolipidemic effects of a polysaccharide (RTFP) isolated fromTratt fruit on type-2 diabeticmice. The results indicated that the oral administration of RTFP could significantly decrease the body weight, fat, and liver hypertrophy and the levels of fasting blood glucose, serum insulin, and serum lipids of themice. Histopathological observation showed that RTFP could effectively protect the pancreas, liver, and epididymal fat against damage and dysfunction. Real-time quantitative polymerase chain reaction analysis confirmed that the gene expression levels of peroxisome proliferator-activated receptors-γ (), sterol regulatory element-binding protein-1 (), acetyl-CoA carboxylase-1 (), fatty acid synthase (), and glucose-6-phosphatase () were significantly down-regulated in the liver ofmice after treatment with RTFP. Moreover, RTFP treatment reversed gut dysbiosis by lowering the-to-ratio and enhancing the relative abundances of beneficial bacteria including,S24-7 group, and. These findings suggest that RTFP can be used as a promising functional supplement for the prevention and treatment of type-2 diabetes mellitus.

Study Type : Animal Study

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