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Abstract Title:

Chemical structure and anti-inflammatory effect of polysaccharide extracted from Morinda citrifolia Linn (Noni).

Abstract Source:

Carbohydr Polym. 2018 Oct 1 ;197:515-523. Epub 2018 Jun 9. PMID: 30007642

Abstract Author(s):

Stefany Guimarães Sousa, Lorena Almeida Oliveira, Diva de Aguiar Magalhães, Tarcisio Vieira de Brito, Jalles Arruda Batista, Cynthia Maria Carvalho Pereira, Mariana de Souza Costa, José Carlos Raposo Mazulo, Marcelo de Carvalho Filgueiras, Daniel Fernando Pereira Vasconselos, Durcilene Alves da Silva, Francisco Clark Nogueira Barros, Venícios G Sombra, Ana Lúcia Ponte Freitas, Regina Célia Monteiro de Paula, Judith Pessoa de Andrade Feitosa, André Luiz Dos Reis Barbosa

Article Affiliation:

Stefany Guimarães Sousa

Abstract:

Polysaccharides extracted from plants are very promising molecules in the field of pharmacotherapy. Knowing this, the aim of this study was to extract, characterize and evaluate the action of the polysaccharide of Morinda citrifolia Linn (Noni-PLS) in biological models of inflammatory processes. The characterization tests shown that sample refers to a heteropolysaccharide composed mainly of homogalacturonan and rhamnogalacturonan. This polysaccharide at dose of 10 mg/kg, when tested in our models of inflammation, showed significant activity in reducing carrageenan-induced paw oedema as well as all mediators edemas. This polysaccharide was able to inhibit the migration of leukocytes to the site of inflammation, and still reduced inflammatory nociception tests. This results, allows us to conclude that the polysaccharide extracted from Morinda citrifolia linn has anti-inflammatory potential since it reversed inflammatory parameters such as edema, leukocyte migration and nociception.

Study Type : Animal Study

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