Article Publish Status: FREE
Abstract Title:

Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice.

Abstract Source:

Genes Nutr. 2007 Oct ;2(1):111-3. PMID: 18850155

Abstract Author(s):

M J Bermúdez-Soto, M Larrosa, J García-Cantalejo, J C Espín, F A Tomás-Barberan, M T García-Conesa

Article Affiliation:

M J Bermúdez-Soto


Berries and red fruits are important dietary sources of polyphenols [1]. In vitro and animal studies have demonstrated the bioavailability and the anti-proliferative and anticarcinogenic properties of these fruits or of their phenolic components [2, 3]. Consumption of berries may contribute to the reduction of colon cancer by mechanisms not yet understood. Gene expression analysis using microarrays allows for a more comprehensive study of the possible molecular mechanisms by which food or food components may prevent certain cancers of the gastrointestinal tract [4]. The aim of this research is to investigate the anti-proliferative effects of a polyphenol-rich berry juice on a human model of colon cancer cells and its association to transcriptional changes in relation to colon cancer.

Study Type : In Vitro Study

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