Article Publish Status: FREE
Abstract Title:

PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα.

Abstract Source:

PLoS One. 2016 ;11(1):e0146393. Epub 2016 Jan 8. PMID: 26744842

Abstract Author(s):

Xiaoyu Hu, Fang Huang, Magdalena Szymusiak, Xuebi Tian, Ying Liu, Zaijie Jim Wang

Article Affiliation:

Xiaoyu Hu

Abstract:

Opioid-induced hyperalgesia (OIH) is one of the major problems associated with prolonged use of opioids for the treatment of chronic pain. Effective treatment for OIH is lacking. In this study, we examined the efficacy and preliminary mechanism of curcumin in attenuating OIH. We employed a newly developed PLGA-curcumin nanoformulation (PLGA-curcumin) in order to improve the solubility of curcumin, which has been a major obstacle in properly characterizing curcumin's mechanism of action and efficacy. We found that curcumin administered intrathecally or orally significantly attenuated hyperalgesia in mice with morphine-induced OIH. Furthermore, we demonstrated that the effects of curcumin on OIH correlated with the suppression of chronic morphine-induced CaMKIIα activation in the superficial laminae of the spinal dorsal horn. These data suggest that PLGA-curcumin may reverse OIH possibly by inhibiting CaMKIIα and its downstream signaling.

Study Type : Animal Study
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