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Abstract Title:

Piperine synergistically enhances the effect of temozolomide against temozolomide-resistant human glioma cell lines.

Abstract Source:

Bioengineered. 2020 12 ;11(1):791-800. PMID: 32693671

Abstract Author(s):

Somi Jeong, Seunghwa Jung, Gyun-Seok Park, Juhyun Shin, Jae-Wook Oh

Article Affiliation:

Somi Jeong

Abstract:

Temozolomide (TMZ) is an alkylating chemotherapy agent used in the clinical treatment of glioblastoma multiforme (GBM) patients. Piperine (PIP) is a naturally occurring pungent nitrogenous substance present in the fruits of peppers. We investigated the anti-cancer efficacies of PIP alone and in combination with TMZ in GBM cellsusingparameters such as cell proliferation, cellular apoptosis,caspase-8/-9/-3 activities, cell cycle kinetics, wound-healing ability, and loss of mitochondrial membrane potential (MMP). Treatment with PIP and alow concentration of PIP-TMZ, inhibited cell growth, similar to TMZ.PIP-TMZ promoted apoptosis by activation of caspase-8/-9/-3, MMP loss, and inhibition ofwound-healing motility. Reverse transcription polymerase chain reaction analysis showed significant inhibition of(andexpression upon treatment with a low concentration PIP-TMZ, suggesting an S to G1 arrest. Our findings provide insight into the apoptotic potential of the combination of a low concentration of PIP-TMZ, though furtherstudy will be needed for its validation.

Study Type : In Vitro Study

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