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Abstract Title:

Piperine protects LPS-induced mastitis by inhibiting inflammatory response.

Abstract Source:

Int Immunopharmacol. 2020 Jul 21 ;87:106804. Epub 2020 Jul 21. PMID: 32707496

Abstract Author(s):

Shan Yu, Xueshibojie Liu, Duo Yu, Changyong E, Jinghui Yang

Article Affiliation:

Shan Yu

Abstract:

Mastitis, inflammation in the breast, affects breastfeedingwomenin the postpartumperiod. In the present study, we investigated the protective effects of piperine against mastitis using a mouse mastitis model. LPS-induced mastitis was established by injecting LPS into the canals of the mammary gland. Piperine was given intraperitoneally 1 h before and 12 h after LPS treatment. The results showed that the LPS-induced mammary histopathological changes and MPO activity were attenuated by piperine. LPS-induced inflammatory cytokines TNF-α andIL-1β were also inhibited by piperine. Furthermore, LPS-induced NF-κB activation was suppressed by the treatment with piperine. In addition, we found piperine dose-dependently increased the expression of PPARγ. All of these results suggested that piperine had protective effects against LPS-induced mastitis and that the mechanism may be mediated through the activation of PPARγ.

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