Abstract Title:

Blood pressure lowering and vasomodulator effects of piperine.

Abstract Source:

J Cardiovasc Pharmacol. 2008 Nov;52(5):452-458. PMID: 19033825

Abstract Author(s):

Syed Intasar Husain Taqvi, Abdul Jabbar Shah, Anwarul Hassan Gilani

Abstract:

Excerpt: "This study was aimed to explore underlying mechanism(s) of cardiovascular effects of piperine. Intravenous administration of piperine caused a dose-dependent (1 to 10 mg/kg) decrease in mean arterial pressure (MAP) in normotensive anesthetized rats; the next higher dose (30 mg/kg) did not cause any further change in MAP. The fall in blood pressure (BP) was followed by small increase in MAP after each dose. In Langendorrf's rabbit heart preparation, piperine caused partial inhibition and verapamil caused complete inhibition of force and rate of ventricular contractions and coronary flow. In rabbit aortic rings, piperine inhibited high K (80 mM) precontractions and partially inhibited phenylephrine (PE), suggesting Ca channel blockade (CCB), which was further confirmed when pretreatment of tissues with piperine caused rightward shift in Ca concentration-response curves, similar to verapamil. In Ca-free medium, piperine (1 to 30 muM) exhibited vasoconstrictor effect. In rat aorta, piperine demonstrated endothelium-independent vasodilator effect and was more potent against high K precontractions than PE. In bovine coronary artery preparations, piperine inhibited high K precontractions completely. These data indicate that piperine possesses a blood pressure-lowering effect mediated possibly through CCB, while consistent decrease in BP was restricted by associated vasoconstrictor effect. Additionally, species selectivity exists in the CCB effect of piperine."

Study Type : Animal Study
Additional Links

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.