Abstract Title:

Physicochemical characteristics and biological activities of polysaccharides from the leaves of different loquat (Eriobotrya japonica) cultivars.

Abstract Source:

Int J Biol Macromol. 2019 May 22 ;135:274-281. Epub 2019 May 22. PMID: 31128186

Abstract Author(s):

Yuan Fu, Qin Yuan, Shang Lin, Wen Liu, Gang Du, Li Zhao, Qing Zhang, De-Rong Lin, Yun-Tao Liu, Wen Qin, De-Qiang Li, Ding-Tao Wu

Article Affiliation:

Yuan Fu


In order to explore polysaccharides from loquat leaves (LLPs) as functional food ingredients for prevention and treatment of obesity and type 2 diabetes, the physicochemical characteristics, in vitro binding properties, and inhibitory effects onα-amylase and α-glucosidase of polysaccharides from the leaves of different loquat cultivars, including 'Baiyu', 'Chuannong8', 'Yuanbao', and 'Dawuxing', were investigated and compared. Results showed that the contents of total uronic acids and degree of esterification in LLPs ranged from (27.04 ± 1.76)% to (41.46 ± 1.91)%, and from (20.54 ± 0.11)% to (26.90 ± 0.10)%, respectively. The weight-average molecular weights of LLPs ranged from 4.307 × 10 Da to 5.101 × 10 Da, and the major constituent monosaccharides of LLPs were rhamnose, galacturonic acid, arabinose, and galactose. Furthermore, LLPs exerted strong in vitro fat binding, cholesterol binding, and bile acid binding capacities, as well as remarkable inhibitory effects on α-amylase and α-glucosidase, which might be attributed to their molecular weights, molecular weight distributions, and degree of esterification. Results are helpful for better understanding of chemical structures and bioactivities of polysaccharides from loquat leaves, and LLPs had good potential to be explored as functionalfood ingredients for prevention and treatment of obesity and type 2 diabetes.

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