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Article Publish Status: FREE
Abstract Title:

Phenolic enriched extract of Baccharis trimera presents anti-inflammatory and antioxidant activities.

Abstract Source:

Molecules. 2012 Jan 23 ;17(1):1113-23. Epub 2012 Jan 23. PMID: 22269829

Abstract Author(s):

Cristiane B de Oliveira, Lucimara N Comunello, Adroaldo Lunardelli, Robson H Amaral, Melissa G S Pires, Gabriela Lucas da Silva, Vanusa Manfredini, Carmen Regla Vargas, Simone C B Gnoatto, Jarbas R de Oliveira, Grace Gosmann

Article Affiliation:

Cristiane B de Oliveira

Abstract:

Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p<0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p<0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.

Study Type : Animal Study

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