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Article Publish Status: FREE
Abstract Title:

L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice.

Abstract Source:

Nutrients. 2019 Aug 1 ;11(8). Epub 2019 Aug 1. PMID: 31374931

Abstract Author(s):

Laura Micheli, Elena Lucarini, Elena Trallori, Carmen Avagliano, Carmen De Caro, Roberto Russo, Antonio Calignano, Carla Ghelardini, Alessandra Pacini, Lorenzo Di Cesare Mannelli

Article Affiliation:

Laura Micheli

Abstract:

To examine the effects of the alpha-amylase inhibitor isoform 1 called phaseolamin, a standardized extract from white kidney beans (L) was tested against the hallmarks of metabolic syndrome. The efficacy of arepeated treatment withextract (500 mg/kg) was compared with metformin (100 mg/kg) and atorvastatin (10 mg/kg) in a model of metabolic syndrome evoked by prolonged high fat diet (HFD; week 1 to week 19) in C57BL/6 mice. Bean extract and compounds administration started after metabolic syndrome establishment (week 11).extract reduced the body weight overtime, as well as effectively lowered glycaemia, triglycerides, and cholesterol. On week 19, bean extract normalized the HFD-evoked tolerance to glucose and insulin. According to the phytochemical characterization, it inhibited the alpha-amylase activity. Animals treated with the extract were rescued from motor impairments and nociceptive threshold alterations induced by HFD. Specific organs analysis revealed thatextract decreased hepatic steatosis and lipid peroxidation in liver. It protected the heart from HFD oxidative alterations increasing the expression of the detoxifying enzymes catalase and glutathione reductase, and normalizing NADH dehydrogenase level. The histological analysis of aorta showed a protection about the development of fatty streaks in the muscular layers. In conclusion, a prolonged treatment with the standardized extract ofsignificantly reduced several pathological features related to a metabolic syndrome-like condition; a multifactorial approach that candidates this vegetal product as a possible therapeutic option against metabolic syndrome.

Study Type : Animal Study

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