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Article Publish Status: FREE
Abstract Title:

Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 Cellsand.

Abstract Source:

Biomed Res Int. 2016 ;2016:4567580. Epub 2016 Oct 17. PMID: 27830146

Abstract Author(s):

XinGang Lu, Liu Yang, ChengHua Lu, ZhenYu Xu, HongFu Qiu, JiaJia Wu, JingWen Wang, JiaFeng Tong, Yin Zhu, Jie Shen

Article Affiliation:

XinGang Lu

Abstract:

Nowadays, chemotherapy is still the main effective treatment for cancer. Herb prescriptions containing(also known as"Guang-Huo-Xiang") have been widely used in Chinese medicine today. In our research, we found that patchouli alcohol, a compound isolated from the oil of, exerted antitumor ability against human lung cancer A549 cells ability bothand. MTT assay was used to assess cell viability. Hoechst 33342 staining and TUNEL cover glass staining provided the visual evidence of apoptosis. Caspase activity measurement showed that patchouli alcohol activated caspase 9 and caspase 3 of mitochondria-mediated apoptosis. Consistently, patchouli alcohol inhibited the xenograft tumor. Further investigation of the underlying molecular mechanism showed that MAPK and EGFR pathway might contribute to the antitumor effect of patchouli alcohol. Our study proved that patchouli alcohol might be able to serve as a novel antitumor compound in the clinical treatment of lung cancer.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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