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Abstract Title:

Paeonol ameliorates murine alcohol liver disease via mycobiota-mediated Dectin-1/IL-1β signaling pathway.

Abstract Source:

J Leukoc Biol. 2020 Mar 4. Epub 2020 Mar 4. PMID: 32129526

Abstract Author(s):

Jiadi Wu, Daqiang Wu, Kelong Ma, Tianming Wang, Gaoxiang Shi, Jing Shao, Changzhong Wang, Guiming Yan

Article Affiliation:

Jiadi Wu

Abstract:

Alcoholic liver disease (ALD) is caused by long-term consumption of alcohol and has become an important social and medical problem. Intestinal fungal flora (mycobiota) play an important role in ALD, so we used the mycobiota as an entry point to explore the mechanism of action of Paeonol against ALD. Here, we found that Paeonol is effective against ALD inflammatory lesions and relieves liver fat lesions. Furthermore, we found that after the treatment of Paeonol, the fungal dysbiosis is improved, and the fungal abundance is reduced, and the translocation ofβ-glucan to the liver and its mediated Dectin-1/IL-1β signaling pathway is blocked. Our study shows that paeonol ameliorated acute ALD-related inflammatory injury to the liver by alleviating intestinal fungal dysbiosis and inhibiting the mycobiota-mediated Dectin-1/IL-1β signaling pathway.

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