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Abstract Title:

Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimer's disease via activation of adenosine Areceptor.

Abstract Source:

Neurosci Lett. 2020 May 1:135016. Epub 2020 May 1. PMID: 32371159

Abstract Author(s):

Yanying Kong, Qiuju Peng, Nan Lv, Jin Yuan, Zhirong Deng, Xiaolin Liang, Si Chen, Laiyou Wang

Article Affiliation:

Yanying Kong

Abstract:

Alzheimer's disease (AD) is the most common cause of dementia, characterised by advanced cognitive and memory deterioration with no effective treatments available. Previous in vitro and in vivo studies suggest that paeoniflorin (PF), a major bioactive constituent of Radix Paeoniae, might possess anti-dementia properties; however, the underlying mechanism remains unclear. The aim of the current study was to determine the therapeutic effects of PF in a transgenic mouse model of AD and to identify its mechanism. Transgenic mice with five familial AD mutations (5XFAD) were used in this study. We showed that 28 days of PF (5 mg/kg, ip) treatment significantly decreased the escape latency and path length in the Morris water maze test and increased the alternation rate in the T-maze test, compared to the vehicle treatment group. In addition, PF treatment significantly alleviated amyloid β plaque burden, inhibited astrocyte activation, and decreased IL-1β and TNF-α expression in the brain of 5XFAD mice. However, the anti-cognitive deficits, anti-amyloidogenic, and anti-inflammatory effects of PF were abolished by 1,3-dipropyl-8-cyclopentylxanthine (DPCPX, 0.3 mg/kg), an adenosine Areceptor (AR) antagonist. In conclusion, our results suggest that PF might act as a potential therapeutic agent for AD via activation of adenosine AR.

Study Type : Transgenic Animal Study

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