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Article Publish Status: FREE
Abstract Title:

Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells.

Abstract Source:

Oncol Rep. 2018 Mar ;39(3):1052-1062. Epub 2017 Dec 28. PMID: 29286139

Abstract Author(s):

Jia Ouyang, Hui Xu, Ming Li, Xingliang Dai, Fengqing Fu, Xueguang Zhang, Qing Lan

Article Affiliation:

Jia Ouyang

Abstract:

Paeoniflorin (PF), a natural compound isolated from Paeoniae radix, has been shown to exert antitumor effects in various types of human cancers including glioma. However, the mechanism of action is not well understood. S-phase kinase-associated protein (Skp)2 functions as an oncogene in many cancers. In the present study, we investigated whether Skp2 mediates the anti-glioma activity of PF. We found that PF inhibited glioma cell proliferation, migration and invasion, and induced G2/M arrest and apoptosis. Skp2 expression was downregulated in glioma cells treated with PF. PF-induced antitumor effects in glioma cells were abolished by Skp2 overexpression but were enhanced by RNA interference of Skp2. Moreover, PF treatment inhibited U87 cell-derived tumor growth in a xenograft mouse model. These results demonstrate that PF exerts its antitumor effects in part by inhibiting Skp2 expression in glioma cells and could be a promising therapeutic agent for glioma therapy.

Study Type : In Vitro Study

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Sayer Ji
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