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Abstract Title:

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway.

Abstract Source:

Fitoterapia. 2014 Dec ;99:318-27. Epub 2014 Oct 16. PMID: 25454463

Abstract Author(s):

Yanling Zhao, Xiao Ma, Jiabo Wang, Yun Zhu, Ruisheng Li, Jian Wang, Xuan He, Limei Shan, Ruilin Wang, Lifu Wang, Yonggang Li, Xiaohe Xiao

Article Affiliation:

Yanling Zhao

Abstract:

HIF-1α/mTOR signaling pathway is considered to play a crucial role in genesis and progress of tissue fibrosis. The elevation of HIF-1α and mTOR is relevant to CCl4 induced liver fibrotic rats. Paeoniflorin has been consistently shown to exhibit multiple pharmacological effects in liver disease. However, so far, no research demonstrates the relationship between paeoniflorin and HIF-1α/mTOR fibrogenesis pathway in liver fibrosis. In this study, the liver fibrosis was performed by CCl4 rats and HSC-T6 cell line. The data demonstrated that paeoniflorin treatment could attenuate liver fibrosis and inhibit the activation of HSC. Moreover, paeoniflorin significantly enhanced hepatic function by decreasing serum level of ALT, AST and ALP, and increasing level of ALB, TP. Meanwhile, ECM degradation was modulated by paeoniflorin treated rats with a remarkable reduce of α-SMA and collagen III mRNA expression. Moreover, the alleviation effect of liver fibrosis was relevant to inhibiting HIF-1α and phosphor-mTOR. Our data indicate that paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α expression partly through mTOR pathway and paeoniflorin may be a potential therapeutic agent for liver fibrosis.

Study Type : In Vitro Study

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