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Abstract Title:

Ozone depletes tocopherols and tocotrienols topically applied to murine skin.

Abstract Source:

FEBS Lett. 1997 Jan 20 ;401(2-3):167-70. PMID: 9013880

Abstract Author(s):

J J Thiele, M G Traber, M Podda, K Tsang, C E Cross, L Packer

Article Affiliation:

J J Thiele

Abstract:

To evaluate ozone damage to hairless mouse skin, two parameters of oxidative damage, vitamin E depletion and malondialdehyde (MDA) production, were measured in vitamin E-enriched and in control skin from mice exposed to ozone (10 ppm). A 5% vitamin E solution (tocotrienol-rich fraction, TRF) in polyethylene glycol (PEG) was applied to 2 sites on the back of hairless mice, PEG to 2 sites. After 2 h, the sites were washed, one of each pair of sites covered and the mice exposed ozone for 2 h. Ozone exposure (compared with covered sites) increased epidermal MDA in PEG-treated sites, while vitamin E was unchanged. In contrast, ozone exposure significantly depleted vitamin E in TRF-treated sites, while significant MDA accumulation was prevented. This is the first demonstration that ozone exposure causes damage to cutaneous lipids, an effect which can be attenuated by vitamin E application.

Study Type : Animal Study

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