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Article Publish Status: FREE
Abstract Title:

Newborn screening for autism: in search of candidate biomarkers.

Abstract Source:

Biomark Med. 2013 Apr ;7(2):247-60. PMID: 23547820

Abstract Author(s):

Gerald J Mizejewski, Barbara Lindau-Shepard, Kenneth A Pass

Article Affiliation:

Gerald J Mizejewski

Abstract:

BACKGROUND: Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment.

AIM: This retrospective study sought to identify newborns at risk for ASD utilizing bloodspot specimens in an immunoassay.

MATERIALS & METHODS: The present study utilized stored frozen specimens from ASD children already diagnosed at 15-36 months of age. The newborn specimens and controls were analyzed by immunoassay in a multiplex system that included 90 serum biomarkers and subjected to statisical analysis.

RESULTS: Three sets of five biomarkers associated with ASD were found that differed from control groups. The 15 candidate biomarkers were then discussed regarding their association with ASD.

CONCLUSION: This study determined that a statistically selected panel of 15 biomarkers successfully discriminated presumptive newborns at risk for ASD from those of nonaffected controls.

Study Type : Human Study

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Sayer Ji
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