Abstract Title:

Neonatal outcomes of assisted and naturally conceived twins: systematic review and meta-analysis.

Abstract Source:

J Perinat Med. 2011 Jul 18. Epub 2011 Jul 18. PMID: 21767221

Abstract Author(s):

A Cristina Rossi, Vincenzo D'Addario

Article Affiliation:

Clinic of Obstetrics and Gynecology, "San Giacomo" Hospital, Monopoli, Bari, Italy.

Abstract:

Abstract Objective: To review the neonatal outcomes of assisted reproductive technique (ART) vs. naturally conceived (NC) twins. Methods: A search in PubMed, Medline, EMBASE, and Cochrane library was performed (January 2000-September 2010). Articles reporting outcomes of ART vs. NC twins were classified in controlled and non-controlled studies. A sub-group was limited to unlike sex twins (UST). The MOOSE guidelines were followed. A randomized model was generated if inter-studies heterogeneity was>25%. Inter-group comparison was significant if P<0.05. Results: Thirteen articles were reviewed. In non-controlled studies, outcomes were equal between groups, except for cesarean section rates (ART: 71.8%; NC: 49.6%; P<0.0001; OR: 2.34; 95% CI: 1.55-3.54). Similar results were obtained in controlled studies, except for higher rates of preterm delivery in ART (55%) than in NC (53%) twins (P=0.03; OR: 1.30; 95% CI: 1.03-1.65). UST differed with regard to preterm delivery (ART: 58.6%; NC: 49.5%; P<0.0001; OR: 1.51; 95% CI: 1.25-1.83), and perinatal death (ART: 3.6%; NC: 1.8%; P<0.0001; OR: 1.95; 95% CI: 1.41-2.71). Birth weight differed between groups. Conclusion: ART twins carry increased risk of adverse outcomes. UST are at higher risk of perinatal death, although further studies are needed to assess whether chorionicity impacts on neonatal outcomes after ART.

Study Type : Meta Analysis
Additional Links

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.