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Abstract Title:

Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis.

Abstract Source:

BMC Pharmacol Toxicol. 2020 Jun 23 ;21(1):46. Epub 2020 Jun 23. PMID: 32576255

Abstract Author(s):

Sonia Aroui, Hamadi Fetoui, Abderraouf Kenani

Article Affiliation:

Sonia Aroui

Abstract:

BACKGROUND: Flavonoids, which existed nearly in all fruits and vegetables, are considered as a class of plant-secondary metabolites with a polyphenolic structure and have properties with health-improving potential. Yet, not so many experimental focus on the benefits of flavonoid in vivo after external application. Here we assessed the impacts of naringin in vitro and in vivo in the human glioma U-87 cells implanted into athymic mice.

METHODS: Tumor size and animal survival time were followed in naringin-treated mice bearing subcutaneous gliomas. To define the effects of naringin on angiogenesis, in vitro, tube formation and migration were assayed using endothelial HUVEC cell line.

RESULTS: Low concentration of naringin remarkably inhibited tubulogenesis and reduced cell invasion. Moreover, naringin has been shown to have a toxicity effect on U-87 cells in a dose-dependent way. Furthermore, naringin administration (120 mg/kg/day) applies serious anti-cancer belongings on glioblastoma, as demonstrated by a slow cancer progression.

CONCLUSIONS: Our study has provided the first evidence on the antitumor effect of naringin, which is somehow due to the inhibition of invasion and angiogenesis.

Study Type : In Vitro Study

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