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Abstract Title:

Natural Anti-inflammatory compounds as Drug candidates in Alzheimer's disease.

Abstract Source:

Curr Med Chem. 2020 Jul 30. Epub 2020 Jul 30. PMID: 32744957

Abstract Author(s):

Reyaz Hassan Mir, Abdul Jalil Shah, Roohi Mohi-Ud-Din, Faheem Hyder Potoo, Mohd Akbar Dar, Sanjay M Jachak, Mubashir Hussain Masoodi

Article Affiliation:

Reyaz Hassan Mir

Abstract:

Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment, dementia, oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. So to develop new drugs with protective action against the disease, research is turning to the identification of plant products as a remedy. Natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Phytochemicals including Curcumin, Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid, genistein, obovatol, and Oxyresvertarol were reported molecules for the treatment of AD. Several alkaloids such as galantamine, oridonin, glaucocalyxin B, tetrandrine, berberine, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.

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