Abstract Title:

Myricetin inhibits IL-1beta-induced inflammatory mediators in SW982 human synovial sarcoma cells.

Abstract Source:

Int Immunopharmacol. 2010 Jul ;10(7):812-4. Epub 2010 Apr 18. PMID: 20403460

Abstract Author(s):

Young Soon Lee, Eun Mi Choi

Article Affiliation:

Young Soon Lee


Rheumatoid arthritis (RA) synovial fibroblasts produce inflammatory mediators, which destruct cartilage and bone in RA joint. The aim of this study is to investigate the effect of myricetin on inflammatory cytokine/matrix metalloproteinase (MMP) production and mitogen-activated protein kinases (MAPKs) in IL-1beta-stimulated SW982 synovial cells. Myricetin significantly decreased IL-1beta-induced production of IL-6 and MMP-1 in synovial cells. Moreover, myricetin diminished the phosphorylation of Jun NH2-terminal kinase (JNK) and p38 MAPK. These results suggest that myricetin reduces the production of MMP and IL-6 in SW982 cells by inhibiting MAPKs (JNK and p38).

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