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Article Publish Status: FREE
Abstract Title:

Anti-anxiety and Anti-depressant Like Effects ofin Experimental Models of Anxiety and Depression.

Abstract Source:

Anc Sci Life. 2017 Apr-Jun;36(4):215-219. PMID: 29269974

Abstract Author(s):

Snigdha Sharma, Shailendra Handu, Ashok Kumar Dubey, Prashant Sharma, Pramod Mediratta, Qazi Mushtaq Ahmed

Article Affiliation:

Snigdha Sharma

Abstract:

Background: Presence of free radical scavenging activity in, commonly known as Curry leaves, has been shown in previous studies. Oxidative stress plays an important role in the development of various neurobehavioral disorders including anxiety and depression.

Aim: The present study aimed to evaluate the effects ofin animal models of depression and anxiety.

Materials and Methods: The effect of incremental doses ofaqueous leaf extract was evaluated on spontaneous motor activity (SMA), open arm incursions in elevated plus maze, and despair behaviour in forced swim (FST) and tail suspension (TST) tests as compared to control groups in Swiss albino mice.

Results: 300 mg/kg, p.o. (MK300) and 400 mg/kg, p.o. (MK400) reduced the SMA count from 754± 64.9 to 540 ± 29 and 295 ± 34 respectively, which was statistically significant. MK300 and MK400 reduced significantly the open arm count from 29 ± 8.6 to 16 ± 7 and 10 ± 3.9, respectively. On FST, MK400 reduced the duration of immobility from 145.5 ± 29 to 91 ± 17.3, which was statistically significant. On TST, MK produced a dose-dependent decrease in the duration of immobility; however, it was statistically significant only with MK400.

Conclusion: aqueous leaf extract reduced the despair behavior in experimental animal models, suggesting an anti-depressant like activity.extract also reduced spontaneous locomotor activity in a dose-dependent manner suggesting a sedative and/or anxiolytic effect though there wasn't any anxiolytic effect in the elevated plus maze test.

Study Type : Animal Study

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