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Abstract Title:

Clinical Relevance and Antimicrobial Profiling of Methicillin-Resistant(MRSA) on Routine Antibiotics and Ethanol Extract of Mango Kernel (L.).

Abstract Source:

Biomed Res Int. 2020 ;2020:4150678. Epub 2020 Feb 18. PMID: 32149104

Abstract Author(s):

Ali Al Bshabshe, Martin R P Joseph, Amgad A Awad El-Gied, Abdalla N Fadul, Harish C Chandramoorthy, Mohamed E Hamid

Article Affiliation:

Ali Al Bshabshe

Abstract:

Methicillin-resistant(MRSA) is known for serious health problems. Testing new inexpensive natural products such as mango kernel (L., Anacardiaceae) may provide alternative and economically viable anti-MRSA drugs. In the current study, we screened clinical isolates from Aseer Central Hospital, Saudi Arabia, during 2012-2017 for MRSA and tested an ethanolic extract of mango kernel for anti-MRSA activity. Brief confirmation of MRSA was performed by the Vitek 2 system, while antibiotic sensitivity of strains was tested for their clinical relevance. Thedisc diffusion method was used to test the anti-MRSA activity of the ethanolic mango kernel extract. The antimicrobial activity of mango kernel was compared to that of standard drugs (oxacillin and vancomycin). Of the identified 132strains, 42 (31.8%) were found to be MRSA and their prevalence showed a clear increase during the last two years (2016-2017;<0.001). MRSA strains showed 100% sensitivity to vancomycin, teicoplanin, linezolid, tetracycline, daptomycin, tigecycline, and tobramycin and 100% resistance to ampicillin and 98% to penicillin. The ethanolic extracts of mango kernel were found active against bothand the MRSA strains. Inhibitory activities (mean ± SE) were achieved at concentrations of 50 mg/mL (20.77 ± 0.61), 5 mg/mL (16.18 ± 0.34), and 0.5 mg/mL (8.39 ± 0.33) exceeding that of vancomycin (=0.0162). MRSA strains were sensitive to mango kernel extracts when compared to vancomycin. Therefore, ethanolic extracts of mango kernel can be escalated to animal model studies as a promising leading anti-MRSA drug candidate and can be an economic alternative to high-priced synthetic antibiotics.

Study Type : In Vitro Study

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