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Abstract Title:

Morusin inhibited human osteosarcoma via PI3K-AKT signaling pathway.

Abstract Source:

Curr Pharm Biotechnol. 2020 Apr 15. Epub 2020 Apr 15. PMID: 32297574

Abstract Author(s):

Yong Zhang, Qiuyan Weng, Jianming Chen, Jinming Han

Article Affiliation:

Yong Zhang

Abstract:

Osteosarcoma is considered as one of the most common types of bone tumors occurs among adolescents and children. Current therapy strategies still have limited effectiveness; therefore, the development of new therapies is urgent. Morusin is a compound isolated from Morus australis (Moraceae). Many studies have reported its anti-tumor effect on several tumor types. However, its role in osteosarcoma is still unclear. In this study, we determined that morusin significantly suppresses the proliferation of osteosarcoma cells. Morusin also promotes the apoptosis of osteosarcoma cells. Furthermore, the migration and invasion of osteosarcoma were reduced after exposure to morusin. The deep mechanism was determined to be the inhibition of the PI3K/AKT signaling pathway. In conclusion, our study indicates morusin as a potential candidate for osteosarcoma therapy.

Study Type : In Vitro Study

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Sayer Ji
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