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Article Publish Status: FREE
Abstract Title:

Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling.

Abstract Source:

Biosci Rep. 2019 06 28 ;39(6). Epub 2019 Jun 20. PMID: 31171712

Abstract Author(s):

Cunrong Chen, Jingjing Wang, Jianfei Chen, Lili Zhou, Hui Wang, Junnian Chen, Zhihui Xu, Shuaijun Zhu, Wei Liu, Ranjie Yu, Junli Lu, Haoteng Luo, Min Chen, Weiwen Chen

Article Affiliation:

Cunrong Chen

Abstract:

Morusin has been traditionally used for the treatment ofpneumonia (MPP), but the underlying mechanism remains elusive. The present study aimed to explore the mechanism by which morusin achieves efficacy on mycoplasma pneumonia. Mycoplasma pneumonia model was established in BALB/c mouse and the effects of morusin were evaluated in the model. Compared with the model group, DNA amount ofdecreased by 24.6± 3.14% and 47.6 ± 6.78% in low morusin (20 mg/kg) and high morusin (50 mg/kg) groups, respectively (<0.05). Moreover, morusin treatment led to decreased levels of pro-inflammatory cytokines such as interleukin (IL)-6, IL-1β, and tumor necrosis factor α and increased level of anti-inflammatory IL-10 in mice lung tissue. Furthermore, morusin treatment inhibited the activation of Wnt/β-catenin and NF-κB pathways in mice lung tissue. Taken together, our results suggest that morusin relieves mycoplasma pneumonia via the inhibition of the activation of Wnt/β-catenin and NF-κB pathways, and is a potential natural agent for the treatment of mycoplasma pneumonia.

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