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Abstract Title:

Morin treatment for acute ethanol exposure in rats.

Abstract Source:

Biotech Histochem. 2020 Jun 29:1-12. Epub 2020 Jun 29. PMID: 32597243

Abstract Author(s):

Anbu Singaravelu, Karthikkumar Venkatachalam, Richard L Jayaraj, Padma Jayabalan, Saravanan Nadanam

Article Affiliation:

Anbu Singaravelu

Abstract:

Ethanol intoxication increases oxidative stress and pro-inflammatory proteins, which cause neurodegeneration. Morin is a natural flavonoid obtained from plants of the Moraceae family that exhibits antioxidant, anti-inflammatory, hepatoprotective, anticancer and cardioprotective properties. We investigated the neuroprotective effect of morin on ethanol intoxicated rats. Rats exposed to ethanol exhibit increased cholesterol, triglycerides, phospholipids, free fatty acids, and lipid oxidative byproducts, and decreased the activity of antioxidant enzymes and membrane ATPase. We found that ethanol increased activation of microglia and astrocytes in the brain. Administration of morin to rats exposed to ethanol significantly decreased lipid oxidative byproducts, enhanced antioxidant enzymes, normalized lipid levels and decreased microglia and astrocyte activation. Morin exhibits neuroprotective properties against ethanol intoxication by increasing the antioxidant defense mechanism and decreasing the inflammatory response caused by neuroglia and astrocytes.

Study Type : Animal Study

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