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Abstract Title:

Metabolomics Reveals that Momordica charantia Attenuates Metabolic Changes in Experimental Obesity.

Abstract Source:

Phytother Res. 2016 Nov 23. Epub 2016 Nov 23. PMID: 27878888

Abstract Author(s):

Zhi-Gang Gong, Jianbing Zhang, Yong-Jiang Xu

Article Affiliation:

Zhi-Gang Gong

Abstract:

Momordica charantia L., also known as bitter melon, has been shown to ameliorate obesity and insulin resistance. However, metabolic changes regulated by M. charantia in obesity are not clearly understood. In this study, serums obtained from obese and M. charantia-treated mice were analyzed by using gas and liquid chromatography-mass spectrometry, and multivariate statistical analysis was performed by Orthogonal partial least squares discriminant analysis. The results from this study indicated that body weight fat and insulin levels of obese mice are dramatically suppressed by 8 weeks of dietary supplementation of M. charantia. Metabolomic data revealed that overproductions of energy and nutrient metabolism in obese mice were restored byM. charantia treatment. The antiinflammatory and inhibition of insulin resistance effect of M. charantia in obesity was illustrated with the restoration of free fatty acids and eicosanoids. The findings achieved in this study further strengthen the therapeutic value of using M. charantia to treat obesity. Copyright © 2016 John Wiley&Sons, Ltd.

Study Type : Animal Study

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