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Article Publish Status: FREE
Abstract Title:

Melittin fromVenom as a Promising Therapeutic Agent for Skin Cancer Treatment.

Abstract Source:

Antibiotics (Basel). 2020 Aug 14 ;9(8). Epub 2020 Aug 14. PMID: 32823904

Abstract Author(s):

Sirikwan Sangboonruang, Kuntida Kitidee, Panuwan Chantawannakul, Khajornsak Tragoolpua, Yingmanee Tragoolpua

Article Affiliation:

Sirikwan Sangboonruang

Abstract:

Melittin, a major component found in bee venom, is produced by thespecies of the honey bee. In this study, the effect of melittin derived from(Mel-AF), which is a wild honey bee species that is indigenous to Thailand, was investigated against human malignant melanoma (A375) cells. In this study, Mel-AF exhibited considerable potential in the anti-proliferative action of A375 cells. Subsequently, the cellular mechanism of Mel-AF that induced cell death was investigated in terms of apoptosis. As a result, gene and protein expression levels, which indicated the activation of cytochrome-c release and caspase-9 expression, eventually triggered the release of the caspase-3 executioner upon Mel-AF. We then determined that apoptosis-mediated cell death was carried out through the intrinsic mitochondrial pathway. Moreover, advanced abilities, including cell motility and invasion, were significantly suppressed. Mel-AF manipulated the actin arrangement via the trapping of stress fibers that were found underneath the membrane, which resulted in the defective actin cytoskeleton organization. Consequently, the expression of EGFR, a binding protein to F-actin, was also found to be suppressed. This outcome strongly supports the effects of Mel-AF in the inhibition of progressive malignant activity through the disruption of actin cytoskeleton-EGFR interaction and the EGFR signaling system. Thus, the findings of our current study indicate the potential usefulness of Mel-AF in cancer treatments as an apoptosis inducer and a potential actin-targeting agent.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Chemopreventive : CK(4220) : AC(1326)

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